03-21-2024, 06:13 AM
[color=var(--text-primary)][color=var(--tw-prose-body)]The primary mode of elimination for sildenafil citrate, the active ingredient in Fildena 150 mg, is hepatic metabolism. After oral administration, sildenafil citrate is rapidly absorbed from the gastrointestinal tract and undergoes extensive metabolism in the liver by the hepatic enzyme cytochrome P450 3A4 (CYP3A4) and to a lesser extent by cytochrome P450 2C9 (CYP2C9).
The metabolites of sildenafil citrate are primarily excreted in Fildena 150 mg feces (approximately 80%) and to a lesser extent in the urine (approximately 13%). Only a small fraction of the administered dose is excreted unchanged in the urine.
Therefore, the liver plays a crucial role in metabolizing sildenafil citrate and facilitating its elimination from the body, with the majority of the metabolites being eliminated via the feces. Individuals with hepatic impairment may have altered metabolism and elimination of sildenafil citrate, which may necessitate dosage adjustments or careful monitoring under the guidance of a healthcare provider.[/color]
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The metabolites of sildenafil citrate are primarily excreted in Fildena 150 mg feces (approximately 80%) and to a lesser extent in the urine (approximately 13%). Only a small fraction of the administered dose is excreted unchanged in the urine.
Therefore, the liver plays a crucial role in metabolizing sildenafil citrate and facilitating its elimination from the body, with the majority of the metabolites being eliminated via the feces. Individuals with hepatic impairment may have altered metabolism and elimination of sildenafil citrate, which may necessitate dosage adjustments or careful monitoring under the guidance of a healthcare provider.[/color]
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